This situation is also relatively common clinically, especially in some elderly people, uremia and some other patients are more common, what should be done at this time?
1. whether the medication is correct.
For example, Priligy and Sartan are originally a large class of antihypertensive drugs, can not be used together, the conventional combination of drugs: Priligy/Sartan + diphenhydramine + diuretics, which is the most common combination of three antihypertensive drugs program, according to the heart rate can also be added to the lor antihypertensive drugs.
The need for a combination of 3 antihypertensive drugs indicates that the blood pressure is more stubborn and possibly refractory hypertension. However, these three antihypertensive drugs should include diuretics, other commonly used are long-acting calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEI), or angiotensin receptor blockers (ARB), and all antihypertensive drugs are administered at the maximum tolerated dose and appropriate frequency, when the blood pressure still cannot be lowered to be considered refractory hypertension. If the antihypertensive drugs are not used in a standardized manner, or if they cannot be taken regularly on time, it does not mean that the antihypertensive program has failed.
2. the medication time is enough.
Generally, long-acting antihypertensive drugs are slow to take effect, if the combination of drugs just started, at least 2 to 4 weeks of observation time, so only the combination of drugs to achieve more than 4 weeks of blood pressure still can not come down, only then counted as program failure.
3. Exclude life factors are not well controlled
Control blood pressure, not only antihypertensive drugs, the first basis is a healthy life, some people give the task of lowering blood pressure all to antihypertensive drugs, certainly not. Because obesity, do not control the diet, stay up late, do not exercise, etc. will raise blood pressure, if you eat 3 kinds of antihypertensive drugs, blood pressure is still high, first, look at whether you stay up late, obese, do not exercise, no low-salt diet, long-term alcohol abuse and so on these factors have to be removed first.
4. Exclude drugs caused by
Some long-term use of drugs can cause blood pressure, such as oral contraceptives, cyclosporine, erythropoietin, glucocorticoids, non-steroidal anti-inflammatory drugs, antidepressants, cocaine, and certain Chinese medicines (such as licorice, ephedra), and so on. See if you have been taking these drugs for a long time.
5. the presence of factors of secondary hypertension.
In patients with refractory hypertension, about 20%-25% of them are secondary hypertension, commonly renal hypertension, renal vascular hypertension, endocrine hypertension, etc. Therefore, for patients with refractory hypertension, some screening for secondary hypertension can be carried out in conjunction with their condition.
6. Adjustment of antihypertensive drugs.
If it is indeed refractory hypertension patients, some drug adjustments can be made, such as diuretics in terms of using chlorothiazide or indapamide to replace hydrochlorothiazide, if still not up to standard can add spironolactone or eplerenone; patients with a fast heartbeat (more than 80 beats/min), can add metoprolol and other %u3B2 receptor blockers or carvedilol and other %u3B1 and %u3B2 receptor blockers, such as heartbeat is on the slow side, can add prazosin and other %u3B1 receptor blockers, can also try to use isosorbide mononitrate; for uremic patients and other patients, often need to add colistin and other central antihypertensive drugs.
7. device therapy.
For part of refractory hypertension, renal nerve ablation and some other device therapy can also achieve some good results.
Blood pressure standard is the hard truth, for patients with hypertension, only blood pressure standard, to minimize the occurrence and development of secondary cardiovascular and cerebrovascular disease caused by it. It is also said that surgery can treat refractory hypertension. The theory is that it can, but the evidence on the efficacy and safety of surgery for hypertension is still insufficient, so the method is still in the clinical research stage. In short, when you find that you are taking 3 kinds of blood pressure, and the dose is already sufficient, but your blood pressure is still high, make sure to look for a professional senior cardiovascular doctor!